Anti-Calprotectin IgG

Purification: Purified using Protein G affinity chromatography
Immunogen: Native calprotectin antigen (MRP8/14) purified from human neutrophils
Applications: Immunocytochemistry, Western blot, sandwich ELISA

Faecal calprotectin determination has been shown to be useful in the diagnosis and management of inflammatory bowel disease.

Kerkhoff C, Klempt M & Sorg C. Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim. Biophys. Acta 1998, 1448:200-211
Gebhardt C, Németh J, Angel P & Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem. Pharmacol. 2006, 72:1622-1631
Korndörfer IP, Brueckner F & Skerra A. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins. J. Mol. Biol. 2007, 370:887-898
Sherwood RA. Faecal markers of gastrointestinal inflammation. J. Clin. Pathol. 2012, 64:981-985
Smith LA & Gaya DR. Utility of calprotectin analysis in adult inflammatory bowel disease. World J. Gastroenterol. 2012, 18:6782-6789
Burri, E & Beglinger C. Faecal calprotection - a useful tool in the management of inflammatory bowel disease. Swiss Med. Wkly. 2012, 142:w13557
Lewis JD. The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 2011, 140:1817-1826